Choosing the Right Hyaluronic Acid Serum

Hyaluronic acid is a naturally occurring polysaccharide found in the human body, primarily in the skin, joints, and connective tissues. It acts as a lubricant and shock absorber, and it also plays a vital role in maintaining skin hydration, elasticity, and overall health.

As we grow older, the natural production of hyaluronic acid in our bodies decreases, leading to the visible signs of aging, such as fine lines, wrinkles, and loss of skin firmness.

In this article, we discuss the importance of hyaluronic acid for skin and the benefits that using products like hyaluronic acid serums brings to the skin. We’ll provide tips on choosing a hyaluronic acid serum suitable for your patient’s needs.

Hyaluronic Acid and Skin Aging: Is There a Connection?

As we age, our skin undergoes various changes, both visible and invisible. One of the critical components that plays a crucial role in the aging process is hyaluronic acid (HA). As a person ages, there is a notable decline in the HA content of the skin in the epidermal layer. However, it’s still said to be found in the dermis upon histological analysis.

Although the exact reason for this phenomenon is not fully understood, it was well observed that HA content affects critical processes in the skin that contribute to its youthful appearance, ‌ultimately contributing to visible aging signs, including dehydration, atrophy (or the decline of skin thickness), and a decrease in skin elasticity.

Understanding the connection between hyaluronic acid and aging brings the prospect of exploring the use of hyaluronic acid as a key ingredient in developing effective skincare strategies to combat the signs of aging.

Benefits of Hyaluronic Acid for the Skin

The Inclusion of hyaluronic acid-based products in skincare will aid in restoring and preserving the levels of this essential molecule, leading to improved skin health and a more youthful appearance. Let’s explore some of the key benefits of hyaluronic acid as a skincare ingredient:

Restoration of Protective Skin Barrier

Hyaluronic acid helps restore and maintain the skin’s natural barriers, slowing down the deterioration of the lipid barrier and protecting and fortifying it, which allows the skin to defend itself against environmental age-factors and pollutants.

Hydrating Properties

As a powerful humectant, hyaluronic acid can attract and retain water molecules, providing long-lasting skin hydration and helping to prevent the skin from looking dry and dull. This moisturizing effect also prevents the overproduction of oil that clogs pores and causes breakouts, ultimately contributing to clearer and better looking skin.

Anti-Aging Properties

The decline in natural levels of hyaluronic acid in the skin is associated with the signs of aging; replenishment through products containing this key ingredient helps promote a more youthful, radiant complexion.

When HA hydrates both the stratum corneum and the dermis by drawing water from the dermis to the epidermis and retaining moisture, it leads to a plumper and bouncier skin associated with a youthful appearance.

Similarly, when the lipid barrier is enhanced and protected by HA, the skin can better defend itself against environmental toxins, resulting in a less wrinkled and brighter look.

Tips On Choosing the Best Hyaluronic Acid Serum for Your Patient

Hyaluronic acid is an excellent ingredient that can effectively improve skin health and appearance. To fully enjoy this ingredient’s advantages, select the most appropriate product tailored for your patient’s needs, which can be achieved by considering the following recommendations:

Consider your patient’s specific skin concern

It’s essential to consider your patient’s specific skin concern when looking for the ideal hyaluronic acid serum. Hyaluronic acid serums may have either high-molecular-weight HA or low molecular weight HA, or a combination of both in different concentrations.

Hyaluronic acid serums containing high concentrations of high-molecular-weight HA focus on hydration by containing a larger molecular size, forming a protective layer on the skin’s surface, retaining moisture, and providing a plumping effect.

Alternatively, serums with high concentrations of low-molecular-weight HA tend to target anti-aging concerns. The smaller molecules of low-molecular-weight HA can penetrate deeper into the skin, promoting collagen production, reducing the appearance of fine lines, and improving skin elasticity.

Check for helpful ingredients

As a skincare ingredient, hyaluronic acid was observed to be compatible with other active ingredients that can help improve skin health and appearance, helping enhance the delivery and absorption of these bioactive compounds.

Some widely used active ingredients work well when formulated with hyaluronic acid; they include probiotics, amino acids, peptides, and proteins, enhancing overall skincare benefits.

Watch for harmful ingredients.

Avoid serums that contain harsh chemicals, fragrances, or other potentially irritating components that could compromise the skin’s health.

Consider choosing serums with pure, unadulterated hyaluronic acid

Some products may contain synthetic or low-quality versions of hyaluronic acid, so it’s important to look for serums that use high-quality, pure HA. This ensures that the product you’ll be applying to your patient’s skin is safe and brings optimum benefits.

Why LH Hyaluronic Acid by Regenomedix is the Best Choice for Anti-Aging

At Regenomedix, we understand the importance of using high-quality, pure hyaluronic acid in our skincare products. Our LH Hyaluronic Acid serum is formulated with low-molecular-weight hyaluronic acid, which is specifically designed to target the visible signs of aging.

The low-molecular-weight HA in our serum is able to penetrate deeper into the skin, reaching the dermal layers where it can have the most significant impact on skin elasticity, hydration, and overall anti-aging benefits. Unlike high-molecular-weight HA, which primarily focuses on surface-level hydration, our LH Hyaluronic Acid serum works to address the underlying causes of aging, helping restore the skin’s youthful appearance from within.

By using our LH Hyaluronic Acid serum, you can expect to see a noticeable improvement in your patient’s skin, specifically in the appearance of fine lines, wrinkles, and overall skin firmness and radiance.

Bring the transformative power of our LH Hyaluronic Acid serum to your practice and let your patients experience its revolutionary effects. Don’t settle for anything less than the best when it comes to bringing skin improvements for your patients.

Can Hyaluronic Acid Serums Be Used After Microneedling for More Optimum Results?

Microneedling is a popular procedure that reveals better looking skin, with visibly improved skin texture. The process involves using tiny needles to intentionally create micro-injuries on the skin, stimulating the skin’s natural healing response and encouraging collagen and elastin production.

Hyaluronic acid serums like LH Hyaluronic Acid by RegenOMedix™ are ideal products to apply to your patient’s skin post-procedurally, as they can help enhance the results brought by microneedling through a more pronounced effect on hydration and anti-aging, while also helping soothe skin irritation, which is a minor side effect of microneedling, thereby reducing the downtime associated with the procedure.

Applying a high-quality hyaluronic acid serum immediately after a microneedling session can maximize both treatments’ benefits. The serum can reach the deeper layers of the skin, providing a boost of hydration and nourishment to the newly stimulated cells. This can lead to faster healing, reduced inflammation, and more visible improvements in appearance.

It’s important to note that when using hyaluronic acid serums after microneedling, it’s crucial to choose a formula that is free of harsh chemicals, fragrances, and other potentially irritating ingredients. It’s also essential to use a gentle and soothing serum after the treatment, as the skin is more at a more vulnerable state after the process and requires support for its healing and rejuvenation process.

Premium Skincare Products by RegenOMedix™

Including hyaluronic acid serums in your product offerings, especially after aesthetic procedures, is an excellent way to ensure that your patients experience only the best results of combating the visible signs of aging and maintaining a healthy, youthful-looking complexion.

Remember to consider factors such as the molecular weight of the HA, the presence of additional beneficial ingredients, and the overall quality and purity of the formula when choosing which product you will offer to your patients.

At RegenOMedix™, we offer high-quality skincare products that can complement the exceptional results brought by the procedures you provide through your expertise in aesthetics. We also offer trustworthy and durable equipment for such procedures, ensuring you consistently deliver the best possible results for your clients.

Call us today for more case studies on the efficacy of this remarkable ingredient and learn more about how our products can help your aesthetic practice.



Bravo B, Correia P, Gonçalves Junior JE, Sant’Anna B, Kerob D. Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence. Dermatol Ther. 2022 Dec;35(12):e15903. doi: 10.1111/dth.15903. Epub 2022 Oct 21. PMID: 36200921; PMCID: PMC10078143.


Draelos ZD, Diaz I, Namkoong J, Wu J, Boyd T. Efficacy Evaluation of a Topical Hyaluronic Acid Serum in Facial Photoaging. Dermatol Ther (Heidelb). 2021 Aug;11(4):1385-1394. doi: 10.1007/s13555-021-00566-0. Epub 2021 Jun 26. PMID: 34176098; PMCID: PMC8322246.


Juncan AM, Moisă DG, Santini A, Morgovan C, Rus LL, Vonica-Țincu AL, Loghin F. Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals. Molecules. 2021 Jul 22;26(15):4429. doi: 10.3390/molecules26154429. PMID: 34361586; PMCID: PMC8347214.


Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. Dermatoendocrinol. 2012 Jul 1;4(3):253-8. doi: 10.4161/derm.21923. PMID: 23467280; PMCID: PMC3583886.


Sundaram H, Cegielska A, Wojciechowska A, Delobel P. Prospective, Randomized, Investigator-Blinded, Split-Face Evaluation of a Topical Crosslinked Hyaluronic Acid Serum for Post-Procedural Improvement of Skin Quality and Biomechanical Attributes. J Drugs Dermatol. 2018 Apr 1;17(4):442-450. PMID: 29601621.

author avatar

Recent Studies & Publications